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Sildenafil Treatment of Women with Antidepressant-Associated Sexual Dysfunction
Authors: H. George Nurnberg, MD; Paula L. Hensley, MD; Julia R. Heiman, PhD; Harry A.
Croft, MD; Charles Debattista, MD; Susan Paine, MPH
Source: JAMA. 2008;300(4):395-404.
Background
Many hopes and fantasies were related to Sildenefil since it emerged in 1998. Many of those regarded the feasibility to use Viagra as a medication for female sexual dysfunction. A pile of works with controversial results were published, but only few used these scientific tools, that should make those works considerable. This study is among those few. Antidepressant treatment–associated sexual dysfunction is estimated to occur in 30% to 70% of men and women treated for major depression with first- or second-generation agents, a principal reason for a 3-fold increased risk of nonadherence that approaches 70% in the first months of treatment and leads to increased relapse, recurrence, disability, and resource utilization by affected patients.
Prevalence and predictors of sexual dysfunction 12 months after major trauma: a national study
Authors: Sorensen MD, Wessells H, Rivara FP, Zonies DH, Jurkovich GJ, Wang J,
Mackenzie EJ
Source J Trauma. 2008 Nov;65(5):1045-52; discussion 1052-3.
OBJECTIVE
To determine the prevalence and predictors of sexual dysfunction (SDF) after
moderate-to-severe trauma in a large multicenter study.
Testosterone for low libido in postmenopausal women not taking estrogen
Authors: Davis SR, Moreau M, Kroll R, Bouchard C, Panay N, Gass M, Braunstein GD,
Hirschberg AL, Rodenberg C, Pack S, Koch H, Moufarege A, Studd J; APHRODITE Study
Team
Source: N Engl J Med. 2008 Nov 6;359(19):2005-17.
Background
The logic to treat female sexual dysfunction, hypoactive sexual desire disorder in particular, by using Testosterone is well familiar, but not improved for therapy by many western countries. The works recommending to treat postmenopausal women with androgens, recommend, for safety reasons, to add Estrogen to the androgen treatment regimens.
Tadalafil administered once daily for lower urinary tract symptoms secondary
Authors: Roehrborn CG, McVary KT, Elion-Mboussa A, Viktrup L.
Source: J Urol. 2008 Oct;180(4):1228-34
Background
Phosphodiesterase type 5 inhibitors are widely used to treat erectile dysfunction. Preliminary data have suggested phosphodiesterase type 5 inhibitor efficacy in men with lower urinary tract symptoms associated with clinical benign prostatic hyperplasia. Once daily dosing of Phosphodiesterase type 5 inhibitors is a very current issue in sexual medicine, The long acting PDE5I in particular. This work tests the effect of Sildenefil as a daily dosing agent.
Topical gabapentin in the treatment of localized and generalized vulvodynia
Authors: Boardman LA, Cooper AS, Blais LR, Raker CA.
Source: Obstet Gynecol. 2008 Sep;112(3):579-85.
Background
Vulvodynia in general and Vestibulitis in particular is a common problem ithout a fine solution, this work present another novel preposition.
The efficacy of female condom skills training in HIV risk reduction among
AUTHORS: Choi KH, Hoff C, Gregorich SE, Grinstead O, Gomez C, Hussey W.
SOURCE: Am J Public Health. 2008 Oct;98(10):1841-8.
Background
In view that HIV infection is currently perceived by many people as an ordinary chronic disease, It is even more important to find more ways to limit this plague, which is far from being demolished or even definitely cured.
OBJECTIVES
This work evaluated the efficacy of skills training designed to increase female condom use among women.
Sex-related knowledge, attitudes, and behaviors of U.S. medical students
AUTHORS: Frank E, Coughlin SS, Elon L.
SOURCE: Obstet Gynecol. 2008 Aug;112(2 Pt 1):311-9.
Background: It is well established that many health practitioners avoid issues relating their
patient's sexual function. This tendency does not serve well our patient's best interests. This
study deals with this issue from the view point of STD prevention.
Male circumcision for the prevention of HSV-2 and HPV infections and syphilis
Authors: Tobian AA, Serwadda D, Quinn TC, Kigozi G, Gravitt PE, Laeyendecker O,
Charvat B, Ssempijja V, Riedesel M, Oliver AE, Nowak RG, Moulton LH, Chen MZ, Reynolds
SJ, Wawer MJ, Gray RH. Department of Pathology, School of Medicine, Johns Hopkins
University, Baltimore, MD, USA.
SOURCE: N Engl J Med. 2009 Mar 26;360(13):1298-309.
BACKGROUND
Male circumcision significantly reduced the incidence of human immunodeficiency virus (HIV) infection among men in three clinical trials, but what about other STD's?. This study assessed the efficacy of male circumcision for the prevention of herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) infections and syphilis in HIV-negative adolescent boys and men.
The impact of lower urinary tract symptoms on male sexual health: EpiLUTS
Authors: Wein AJ, Coyne KS, Tubaro A, Sexton CC, Kopp ZS, Aiyer LP.
Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
SOURCE: BJU Int. 2009 Apr;103 Suppl 3:33-41.
OBJECTIVE
The link between LUTS and sexual dysfunction is long known but still controversial, this study was added to our review dew to large group of participants. The current study evaluated the association between International Continence Society categories of lower urinary tract symptoms (LUTS; storage, voiding, and postmicturition) and individual LUTS (associated with decreased sexual activity and sexual satisfaction in men) with erectile dysfunction (ED), ejaculatory dysfunction (EjD) and premature ejaculation (PE).
The clinical association between free androgen index and erectile dysfunction
Authors: Hameed A, Thwaini A, Aslam Z, Shergill I, Ahmed R, Yahia G, Morgan D. Barts
and the London Hospitals, UK.
SOURCE: Can J Urol. 2009 Feb;16(1):4478-83.
Background
Recently more and more practitioners noticed the benefit of replacing testosterone to men with ED who do not sufficiently respond to PDE5I and low or normal low range limits of testosterone. Does this observation is evidence established? This is a very preliminary study.
Condom use and high-risk sexual acts in adult films: a comparison of
Authors: Lee MS, Shin BC, Ernst E. Department of Medical Research, Korea Institute of
Oriental Medicine, Daejeon, South Korea.
SOURCE: BJU Int. 2009 Feb 23.
BACKGROUND
Just to make it clear….
OBJECTIVE
This work evaluated the current evidence for the use of acupuncture to treat erectile dysfunction (ED).
Factors predicting preservation of erectile function in men undergoing open
Authors: Marien T, Sankin A, Lepor H. Department of Urology, New York University
School of Medicine, New York, New York, USA.
SOURCE: J Urol. 2009 Apr;181(4):1817-22.
BACKGROUND
The development of erectile dysfunction represents a major concern for potent men with localized prostate cancer undergoing open radical retropubic prostatectomy.
Acupuncture for treating erectile dysfunction: a systematic review
AUTHORS: Lee MS, Shin BC, Ernst E. Department of Medical Research, Korea Institute of
Oriental Medicine, Daejeon, South Korea.
SOURCE: BJU Int. 2009 Feb 23.
BACKGROUND
Just to make it clear….
OBJECTIVE
This work evaluated the current evidence for the use of acupuncture to treat erectile dysfunction (ED).
Section Editor
Dr. Arik Shechter
Family Physician
Public practice of Sexual Health
Haclalit sick fund
Haifa, Israel
arikshec[at]netvision.net.il