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The Surgical Treatment of Peyronie's Disease: Replacement of Plaque by Free Autograft of Buccal Mucosa

Shioshvili TJ, Kakonashvili AP; European Urology 2005 (48) 129-135

KEY WORDS: Peyronie's disease; Indurative plaque's excision; Buccal mucosa; Clinical results

Results of radical surgical treatment by means of excision or incision of plaque and its replacement with various bio- or alloplastic materials are controversial, as in the available literature, it's not possibly to find any randomized comparative investigations to generalize them. The authors carried out preliminary experiments on 37 dogs using biomaterials most popular in clinics: free autopatches from skin, aponeurosis, peritoneum, vein and buccal mucosa. These data became basic for the use of this material in the clinical practice.The aim of this work was the evaluation of clinical results of the use of buccal mucosa for replacement of Peyronie's disease plaque.

• A total of 26 patients with Peyronie's disease were under observation. All the patients underwent complete investigations before and periodically within 3 years after the treatment. After stabilization in plaque's development (mean time 2.0±0.1 years) the patients underwent a surgery by means of excision of plaque and its replacement by free autograft of buccal mucosa.
• After the surgical treatment in 24 patients out of 26 (92.3%) the complete straightening of penis occurred. The authors concluded that buccal mucosa showed high properties of adaptation and revascularization, good anatomical and functional clinical results by replacement of indurative plaque, it kept a stable elasticity without shrinkage; the method is simple and can be recommended for wide use in clinics for surgical treatment of Peyronie's disease.

See the abstract

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15967262&query_hl=4