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Erectile Function Profiles in Men With Peyronie’s Disease

Deveci S, Palese M, Parker M, Guhring P, Mulhall JP; J Urol. 2006; 175, 1807-1811.

KEY WORDS: penile induration, impotence, penile curvature, hemodynamic processes

The literature supports a relationship between Peyronie's Disease (PD) and erectile dysfunction (ED), but the combined condition complicates the treatment of the patient and usually results in a further decrease in patient health related quality of life. The increased occurrence of ED in patients with Peyronie’s disease may reflect psychological and physiological effects of the disease. In this study, the authors investigated the erectile function status in a total of 222 patients men presenting with Peyronie’s disease and compared between those with onset of ED before and after diagnosis of PD.

• Of the 222 patients, 78 had ED (35%) by self-report at presentation, with mean age of patients with PD and ED 52 ± 22 years old. Hypertension (71.5%), hyperlipidemia (60.4%) and smoking (49.2%) were the leading comorbidities in the entire group. Statistically significant differences were found between the groups with and without ED for hypertension (p = 0.02) and cigarette smoking (p = 0.009). Of 222 patients 45 (20%) had ED that predated PD onset (group 1) and 33 (15%) had ED that postdated the onset of PD (group 2). DICC showed normal hemodynamics in 14 of 78 patients (18%), arteriogenic insufficiency in 50 (64%) and corporoveno-occlusive dysfunction in 16 (20%). CVOD was evenly distributed between groups 1 and 2, whereas arteriogenic ED was significantly higher in group 1 (82%). Site specific leak was seen in 4 of 33 (12%), all group 2 patients.
• A third of patients with PD report ED at presentation and International Index of Erectile Function (IIEF) defined ED rates are slightly higher. When ED follows the onset of PD, the patients are more likely to have normal erectile hemodynamics. In contrast to many previous reports, arteriogenic ED is the most commonly seen vascular diagnosis for ED in men with PD. Site specific leak is an uncommon contributor to ED in patients with PD.

See the abstract

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16600766&query_hl=3&itool=pubmed_docsum