Treatments of Erectile Dysfunction
Uprima (Apomorphine Hydrochloride) is a light brown pentagon (2mg) or triangle (3mg) shaped tablet. It is designed to be taken orally by placing the tablet under the tongue, where it dissolves in about 10 minutes. It is not an aphrodisiac and does not increase sexual desire. For Uprima to be effective sexual stimulation is required.
Uprima is placed under the tongue, where it dissolves and is absorbed. It then acts on a specific area in the brain known to be involved in the erectile process. Here it works via the body's natural signalling pathways and acts to enhance the signals which allow an erection to occur.
Uprima will be available in two strengths - 2mg and 3mg. The recommended starting dose is 2mg. Before taking Uprima it is advised to drink a small amount of water, this helps the tablet to dissolve. The tablet should then be placed under the tongue. In the majority of men the tablet will be completely dissolved within 10 minutes (if any residual amount remains in the mouth after 20 minutes It may be swallowed). If the tablet is swallowed immediately it will not be effective.
The amount of time it takes Uprima to work varies from person to person, but on average it takes between 10 minutes to 20 minutes.
Uprima dissolves under the tongue and is absorbed in the mouth; therefore the ability of the tablet to work and the time it takes to work is not affected by food/meals.
Alcohol consumption can diminish sexual performance. Therefore in order to get the maximum benefit from the medication it is advisable not to drink large amounts of alcohol before taking Uprima
The manufacturers have tested the drug on over 5,000 men during 21 clinical trials. When taken at the recommended doses some side effects have been reported although they were generally mild and transient. The most common side effects are nausea, headache and dizziness.
Patients with the following:
Uprima should be used with caution in patients with:
Uprima should not be taken by women as its safety in women has not been tested.
The recommended starting dose for Uprima is 2mg. The dose may increase on subsequent administrations to 3mg if necessary to reach the desired clinical effect.
Clinical trials have shown that increasing the dose beyond the maximum recommended dose of 3mg simply increases the side effects and not the efficacy.
Uprima can cause dizziness and light-headedness, therefore patients should not drive for at least 2 hours after taking Uprima or until such symptoms are fully resolved.
If Uprima does not help you get the desired clinical effect you should tell your doctor, who will be able to advise you as to whether a dose increase on subsequent administrations to 3mg is necessary to reach the desired clinical effect. Your doctor can also advise you on other possible treatment options.